FRα Expression in Ovarian Cancer
BIOLOGY
Folate receptor alpha (FRα) is a protein responsible for transporting folate into the cell, which is an essential process for normal cell growth and proliferation. However, overexpression of FRα in tumor cells leads to uncontrolled cell growth and proliferation of the tumor.1
Testing Considerations
FRα protein expression may be tested in ovarian cancer. FRα IHC status is often defined by staining intensity when considering the percentage of tumor cells.1
Biomarker Type
Testing Modality
Images are for illustrative purposes only.
Negative
Positive
Biomarker Type
Testing Modaility
Negative
Positive
Images are for illustrative purposes only.
Relevant Resources
Learn more about FRα expression in ovarian cancer by visiting ExploreFRalpha.com
References
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